What genetic condition causes muscle fibers to be particularly vulnerable to damage?

Muscular dystrophy is a group of genetic disorders characterized by progressive muscle weakness and degeneration, primarily due to mutations in genes responsible for muscle structure and function. These mutations lead to a deficiency in proteins that are essential for maintaining the integrity of muscle fibers. As a result, the muscle fibers become particularly susceptible to damage during regular activities. Over time, this vulnerability leads to the progressive loss of muscle mass and strength, significantly impacting mobility and overall physical function.

In contrast, the other conditions listed, such as cystic fibrosis and Down syndrome, do not primarily affect muscle integrity in the same way. Cystic fibrosis primarily impacts the lungs and digestive system, while Down syndrome is a chromosomal disorder that affects various aspects of physical and cognitive development but not specifically muscle fiber integrity. Asthma is a respiratory condition and does not involve direct muscle fiber damage. Thus, muscular dystrophy is specifically linked to the vulnerability of muscle fibers due to its genetic nature.